SEQUENCE CHARACTERIZATION AND EXPRESSION OF HOMEOBOX HOX A7 IN THE MULTI-POTENTIAL ERYTHROLEUKEMIC CELL-LINE TF-1

Homeobox gene expression was examined in the erythroleukaemic cell lin e TF-1. Expression of a number of HOX A, B and C genes, including HOX A7 was detected. Expression of this gene has not previously been repor ted in erythroleukaemic cell lines. A 2.1 kb full length cDNA of the H OX A7 gene was cloned. The predicted amino acid sequence C-terminal to the homeodomain consists of an alanine-rich region and a strongly neg atively charged domain consisting entirely of aspartic and glutamic ac id residues. (C) 1998 Elsevier Science B.V. All rights reserved.