STRUCTURE AND CHROMOSOMAL MAPPING OF THE TNF-ALPHA INDUCIBLE ENDOTHELIAL PROTEIN-1 (EDP1) GENE IN THE MOUSE

EDP1 was identified as a human gene activated transcriptionally by tum our necrosis factor ex in endothelial cells. Here we have characterise d the mouse Edp1 gene. We show that the gene encodes a highly conserve d protein and describe its intron/exon structure. The presence of rela ted genes in the sequence databases suggests that Edp1 is part of a ge ne family. Fine mapping of the gene in the mouse genome indicates that , as expected from its location on human chromosome 17, the mouse Edp1 gene maps to mouse chromosome 11. However, surprisingly, the gene doe s not map to the expected region of mouse chromosome 11 suggesting tha t a change in the order of genes has occurred within a conserved linka ge group. (C) 1998 Elsevier Science B.V. All rights reserved.