INCREASES IN THE LEVELS OF COXIELLA BURNETTI-SPECIFIC IMMUNOGLOBULIN G1 AND G3 ANTIBODIES IN ACUTE Q-FEVER AND CHRONIC Q-FEVER

Authors
CAPO C IORGULESCU I MUTILLOD M MEGE JL RAOULT D
Citation
C. Capo et al., INCREASES IN THE LEVELS OF COXIELLA BURNETTI-SPECIFIC IMMUNOGLOBULIN G1 AND G3 ANTIBODIES IN ACUTE Q-FEVER AND CHRONIC Q-FEVER, Clinical and diagnostic laboratory immunology (Print), 5(6), 1998, pp. 814-816
Citations number
29
Categorie Soggetti
Immunology,"Infectious Diseases",Microbiology
Journal title
Clinical and diagnostic laboratory immunology (Print) → ACNP
ISSN journal
1071412X
Volume
5
Issue
6
Year of publication
1998
Pages
814 - 816
Database
ISI
SICI code
1071-412X(1998)5:6<814:IITLOC>2.0.ZU;2-7
Abstract
A detailed analysis of the humoral response to Coxiella burnetii may p rovide insight into the pathogenesis of Q fever, a zoonosis caused by C. burnetii. The subclasses of C. burnetii-specific antibodies were de termined by immunofluorescence in 20 patients with acute Q fever and 2 0 patients with chronic Q fever. Although immunoglobulin G1 (IgG1) and IgG3 antibodies were found in acute and chronic Q fever, neither IgG2 nor IgG4 was detected. The detection of IgG1 and IgG3 antibodies was nut due to an increase of the IgG1 and IgG3 subclasses. Moreover, IgG1 and IgG3 antibodies were not correlated, suggesting that they may pla y different roles in Q fever.