AGING AND THE IMMUNE-RESPONSE TO TETANUS TOXOID - DIMINISHED FREQUENCY AND LEVEL OF CELLULAR IMMUNE REACTIVITY TO ANTIGENIC-STIMULATION

Authors
SCHATZ D ELLIS T OTTENDORFER E JODOIN E BARRETT D ATKINSON M
Citation
D. Schatz et al., AGING AND THE IMMUNE-RESPONSE TO TETANUS TOXOID - DIMINISHED FREQUENCY AND LEVEL OF CELLULAR IMMUNE REACTIVITY TO ANTIGENIC-STIMULATION, Clinical and diagnostic laboratory immunology (Print), 5(6), 1998, pp. 894-896
Citations number
12
Categorie Soggetti
Immunology,"Infectious Diseases",Microbiology
Journal title
Clinical and diagnostic laboratory immunology (Print) → ACNP
ISSN journal
1071412X
Volume
5
Issue
6
Year of publication
1998
Pages
894 - 896
Database
ISI
SICI code
1071-412X(1998)5:6<894:AATITT>2.0.ZU;2-5
Abstract
The period of efficacious immune reactivity afforded by tetanus immuni zation and the need for continuing some forms of tetanus vaccination p rograms have been the subjects of recent debates. Our studies demonstr ate that the level of antitetanus immunity based on immunological memo ry (i.e., cellular immune responsiveness) varies dramatically as a fun ction of age, with older individuals constituting a population which i s increasingly susceptible to tetanus infection.