Enteric fever continues to be a common and serious problem worldwide,
and the need for reliable and cheap alternatives to culture methods fo
r diagnosis remains. Epidemics of different strains may coexist in the
same geographical area and the rapid emergence of resistance to fluor
oquinolones, independent of plasmid mediated multidrug resistance, mea
ns that alternative drugs for chemotherapy are also needed. Curr Opin
Infect Dis 11:583-590. (C) 1998 Lippincott Williams & Wilkins.