ASSOCIATION BETWEEN BLEOMYCIN HYDROLASE AND ALZHEIMERS-DISEASE IN CAUCASIANS

Authors
FARRER LA ABRAHAM CR HAINES JL ROGAEVA EA SONG YQ MCGRAW WT BRINDLE N PREMKUMAR S SCOTT WK YAMAOKA LH SAUNDERS AM ROSES AD AUERBACH SA SORBI S DUARA R PERICAKVANCE MA STGEORGEHYSLOP PH
Citation
La. Farrer et al., ASSOCIATION BETWEEN BLEOMYCIN HYDROLASE AND ALZHEIMERS-DISEASE IN CAUCASIANS, Annals of neurology, 44(5), 1998, pp. 808-811
Citations number
12
Categorie Soggetti
Clinical Neurology",Neurosciences
Journal title
Annals of neurology → ACNP
ISSN journal
03645134
Volume
44
Issue
5
Year of publication
1998
Pages
808 - 811
Database
ISI
SICI code
0364-5134(1998)44:5<808:ABBHAA>2.0.ZU;2-P
Abstract
A recent study showed modest evidence for an increased frequency of th e bleomycin hydrolase (BH) VN genotype in Alzheimer's disease (AD) pat ients compared with nondemented controls. To test this hypothesis, we examined this polymorphism in 621 rigorously evaluated patients and 50 2 control subjects (all caucasian) but were unable to detect an associ ation between BH and AD even after controlling for age, gender, and ap olipoprotein E (ApoE) genotype. We conclude that this polymorphism doe s not account for inherited susceptibility to AD in the populations re presented in this sample.