GENETIC CONTRIBUTION OF THE TUMOR-NECROSIS-FACTOR REGION IN GUILLAIN-BARRE-SYNDROME

Authors
MA JJ NISHIMURA M MINE H KUROKI S NUKINA M OHTA M SAJI H OBAYASHI H KAWAKAMI H SAIDA T UCHIYAMA T
Citation
Jj. Ma et al., GENETIC CONTRIBUTION OF THE TUMOR-NECROSIS-FACTOR REGION IN GUILLAIN-BARRE-SYNDROME, Annals of neurology, 44(5), 1998, pp. 815-818
Citations number
17
Categorie Soggetti
Clinical Neurology",Neurosciences
Journal title
Annals of neurology → ACNP
ISSN journal
03645134
Volume
44
Issue
5
Year of publication
1998
Pages
815 - 818
Database
ISI
SICI code
0364-5134(1998)44:5<815:GCOTTR>2.0.ZU;2-8
Abstract
We studied genetic polymorphisms in the tumor necrosis factor (TNF) re gion in 81 Japanese patients with Guillain-Barre syndrome (GBS) and 85 controls. A significantly higher frequency of the 100-base pair (bp) (TNFa2) allele of the TNFa microsatellite marker, which is associated with high TNF alpha production, existed in Campylobacter jejuni-positi ve (C-j(+)) GBS patients than in controls, suggesting the involvement of a genetic predisposition to high TNF alpha secretion in the develop ment of C. jejuni-related GBS.