BETA-CHEMOKINES MCP-1 AND RANTES ARE SELECTIVELY INCREASED IN CEREBROSPINAL-FLUID OF PATIENTS WITH HUMAN IMMUNODEFICIENCY VIRUS-ASSOCIATED DEMENTIA

Human immunodeficiency virus-associated dementia (HAD) is associated w ith increased numbers of activated central nervous system (CNS) macrop hages. Chemokines, which regulate infiltration of macrophages, were me asured in the cerebrospinal fluid (CSF) of human immunodeficiency viru s (HIV)-negative and HIV-positive individuals with and without neurolo gical disease. Monocyte chemotactic protein (MCP)-1 and RANTES (but no t MCP-3), macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta, o r interleukin-8 (IL-8) was higher in HAD. MCP-1 correlated with CSF vi ral load and severity of dementia, and it increased over time in patie nts who developed dementia.