PLANAR CHROMATOGRAPHY OF (-)-DEPRENYL AND SOME STRUCTURALLY RELATED-COMPOUNDS

The thin-layer chromatographic behavior of deprenyl and that of some o f its structural analogs has been investigated. R-F values of numerous N-propynyl-N-(2-phenyl-1-methyl)ethylamines are given for characteriz ation of these compounds. Depending on the pH of the aqueous butanol m obile phase, which can be regulated by changing the ratio of ammonia t o acetic acid, use of elution-type separation enables adequate differe ntiation of a variety of compounds structurally related to deprenyl, U se of normal-phase silica with triethanolamine containing chloroform a s displacer and carrier, respectively, was suitable for displacement s eparation. Displaced zones were classified as either bona-fide displac ed or quasi-displaced bands on the basis of the shape of their displac ement train. A useful method is also suggested for establishing the or der of any pair of the compounds in the displacement train. TLC on RP- 18 silica using both elution and displacement development is also intr oduced for separation of N-propynyl-N- (2-phenyl-1-methyl)ethylamines and their structural analogs. Advantages of spacer-displacement chroma tography are presented. Reversed-phase chromatography on paraffin-coat ed silica plates serves for determination of lipophilicity; parameters are given as R-M,R-0 values and slopes.