MMR, A MYCOBACTERIUM-TUBERCULOSIS GENE CONFERRING RESISTANCE TO SMALLCATIONIC DYES AND INHIBITORS

Authors
DEROSSI E BRANZONI M CANTONI R MILANO A RICCARDI G CIFERRI O
Citation
E. Derossi et al., MMR, A MYCOBACTERIUM-TUBERCULOSIS GENE CONFERRING RESISTANCE TO SMALLCATIONIC DYES AND INHIBITORS, Journal of bacteriology (Print), 180(22), 1998, pp. 6068-6071
Citations number
24
Categorie Soggetti
Microbiology
Journal title
Journal of bacteriology (Print) → ACNP
ISSN journal
00219193
Volume
180
Issue
22
Year of publication
1998
Pages
6068 - 6071
Database
ISI
SICI code
0021-9193(1998)180:22<6068:MAMGCR>2.0.ZU;2-M
Abstract
The mmr gene, cloned from Mycobacterium tuberculosis, was shown to con fer to Mycobacterium smegmatis resistance to tetraphenylphosphonium (T PP), erythromycin, ethidium bromide, acriflavine, safranin O, and pyro nin Y. The gene appears to code for a protein containing four transmem brane domains. Studies of [H-3]TPP intracellular accumulation strongly suggest that the resistance mediated by the Mmr protein involves acti ve extrusion of TPP.