RING-CLOSING METATHESIS ON SOLID SUPPORT - ELABORATION OF A CYCLIZATION CLEAVAGE STRATEGY TOWARDS UNSATURATED ALPHA-ESTER-SUBSTITUTED N-HETEROCYCLES/

A Ru-mediated strategy for the cleavage of organic substrate molecules from a solid support via ring-closing metathesis is described. Applic ation of this protocol to solid phase-bound olefinic amino acid deriva tives provides various highly functionalized unsaturated N-heterocycle s of different ring-sizes in moderate to excellent yields. This strate gy features the addition of a stoichiometric amount of styrene to the metathesis mixture, which is shown to increase the yield of the reacti on.