S. Cicchi et al., ENANTIOMERICALLY PURE DENDRIMERS BASED ON A TRANS-3,4-DIHYDROXYPYRROLIDINE, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, (11), 1998, pp. 2591-2597
The synthesis of the first and second generation of enantiopure dendri
mers based on a chiral trans-3,4-dihydroxypyrrolidine is reported. Ben
zenepolycarboxylic acids were used as central nucleus to afford linear
and radial growth, and terephthalic acid was used as spacer between t
he pyrrolidine nuclei. The analysis of the chiroptical properties ([al
pha](D), circular dichroism) of these new dendrimers suggests that tho
se with radial growth present a self organisation of chiral units.