D-2-DOPAMINE-RECEPTOR OCCUPANCY DURING TREATMENT WITH HALOPERIDOL DECANOATE

Citation
J. Scherer et al., D-2-DOPAMINE-RECEPTOR OCCUPANCY DURING TREATMENT WITH HALOPERIDOL DECANOATE, European archives of psychiatry and clinical neuroscience, 247(2), 1997, pp. 104-106
Citations number
12
Categorie Soggetti
Psychiatry,"Clinical Neurology
ISSN journal
09401334
Volume
247
Issue
2
Year of publication
1997
Pages
104 - 106
Database
ISI
SICI code
0940-1334(1997)247:2<104:DODTWH>2.0.ZU;2-C
Abstract
We investigated in an open, explanatory study a total of 24 patients m eeting DSM-III-R criteria for schizophrenia. Eighteen patients were tr eated for at least 4 weeks with a fixed dose of orally administered ha loperidol for at least 4 weeks (mean daily dosage ranging from 0.07 to 0.35 mg/kg b.w.), and 6 patients received haloperidol decanoate with a fixed dose for at least 4 months (dosage range 50-150 mg/4 weeks; ca lculated mean daily dosage ranging from 0.02 to 0.09 mg/kg b.w.). One week after injection of haloperidol decanoate, the single photon emiss ion computed tomography examination was performed. Our data suggest th at D-2-dopamine-receptor occupancy of 50 mg/4 weeks haloperidol decano ate 1 week after injection corresponds to an oral dose of 4.5 mg/day h aloperidol.