GRADIENT-ENHANCED AND SENSITIVITY-ENHANCED HETERONUCLEAR MULTIPLE-QUANTUM CORRELATION SPECTROSCOPY

A gradient- and sensitivity-enhanced HMQC experiment has been develope d. The sensitivity of the experiment is increased by factors of root 2 and 2 over the conventional and gradient-enhanced HMQC experiments, r espectively. This improvement is achieved by retaining both the x and the y magnetization components in the indirectly detected dimension. T his experiment will be particularly useful in NMR studies of large bio molecules as the relaxation time of the multiple-quantum coherence is much longer than that of the single-quantum coherence in the slow moti on limit. (C) 1998 Academic Press.