We examine the effects of instantons in four-dimensional N = 1 supersy
mmetric gauge theory by including D0-branes in type IIA brane construc
tions, We examine instanton-generated superpotentials in supersymmetri
c QCD and find that they are due to a repulsive force between D4-brane
s bound to D0-branes ending on NS 5-branes. We study situations where
instanton effects break supersymmetry such as the Intriligator-Thomas-
Izawa-Yangagida model and relate this to a IIA brane construction. We
also argue how confinement due to a condensate of fractional instanton
s manifests itself in super Yang-Mills theory using fractional D0-bran
es, D4-branes, and NS-strings. (C) 1998 Published by Elsevier Science
B.V.