PHARMACOKINETICS AND BIOAVAILABILITY OF SULFAMONOMETHOXINE IN CULTURED EEL

Sulfamonomethoxine has been shown to be efficacious in the treatment o f various bacterial diseases of fish. The present study examines the p harmacokinetics and bioavailability of sulfamonomethoxine in Japanese ell Anguilla japonica that is the most popular cultured fish in Japan; The pharmacokinetics of sulfamonomethoxine were determined after intr avascular (i.v.), 200 mg/kg body weight, and oral (p.o.), 400 mg/kg bo dy weight, administration. The consentration of sulfamonomethoxine was determined by our high-performance liquid chromatographic method Seru m levels of i.v. could be fitted to a two-compartment model and those of p.o. to a one-compartment model. The area under the serum concentra tion time curve (AUC) was 59,100 and 28,400 mu g.h/m/for i.v. and p.o. , respectively. The bioavailability of sulfamonomethoxine was found to be 24.0%. The acetylation of the drug for i.v. was 3.1%.