EFFECT OF HINDLIMB UNLOADING ON INTERLIMB COORDINATION DURING TREADMILL LOCOMOTION IN THE RAT

Effects of hindlimb unloading on interlimb coordination were examined in adult rats walking on a treadmill at moderate speed. In the first g roup of animals, the electromyographic activity (EMG) of soleus muscle of both hindlimbs was recorded after 7 and 14 days of unloading. In t he second group, the EMG was recorded daily until the 14th day of unlo ading. The general organization of locomotion was preserved in the two groups whatever the duration of the unloading. The step cycles of the two hindlimbs were always strictly alternating. However, the locomoto r pattern was very irregular. A lateral instability was observed. It w as accompanied by an abduction of the hindlimbs, and frequent hyperext ensions of the ankle when walking. The EMG analysis showed an increase in step cycle duration and in coactivation duration of the soleus mus cles (i.e. in the double stance duration). In the rats recorded daily, mean EMG was dramatically reduced the Ist day of unloading, suggestin g a decrease in the neural drive. Taken together, these data indicate that 14 days of hindlimb unloading can alter the neuromuscular pattern during locomotion. It is proposed that these changes are related to c hanges in the peripheral sensory information.