G A(1947) POLYMORPHISM IN CATECHOL-O-METHYLTRANSFERASE (COMT) GENE INPARKINSONS-DISEASE/

Authors
XIE T HO SL LI LSW MA OCK
Citation
T. Xie et al., G A(1947) POLYMORPHISM IN CATECHOL-O-METHYLTRANSFERASE (COMT) GENE INPARKINSONS-DISEASE/, Movement disorders, 12(3), 1997, pp. 426-427
Citations number
7
Categorie Soggetti
Clinical Neurology
Journal title
Movement disorders → ACNP
ISSN journal
08853185
Volume
12
Issue
3
Year of publication
1997
Pages
426 - 427
Database
ISI
SICI code
0885-3185(1997)12:3<426:GAPIC(>2.0.ZU;2-M
Abstract
High and low catechol-O-methyltransferase (COMT) activity is significa ntly determined by thermostability, which is caused by a valine/methio nine(10S) polymorphism associated with polymorphic G/A1947 bases, in e xon 4 of the COMT gene. Our allelic association study on this polymorp hism did not find any statistically significant difference between our Chinese Parkinson's disease and that of control subjects. These resul ts show that this polymorphism and hence the thermostability of COMT e nzyme are not related to a risk of developing Parkinson's disease.