Background: Fast-track cardiac anesthesia, using low-dose narcotics co
mbined with short-acting anesthetic and sedative agents, facilitates e
arly tracheal extubation after cardiac surgery. The incidence of aware
ness with this anesthetic technique has not been investigated previous
ly. The purpose of this study was to prospectively investigate the inc
idence of intraoperative awareness with explicit memory of events duri
ng fast-track cardiac anesthesia. Methods: Data were collected prospec
tively over a 4-month period from 617 consecutive adult patients under
going cardiac surgery at a university hospital. All patients received
a fast-track cardiac anesthetic regimen, Patients underwent a structur
ed interview by a research nurse 18 h after extubation. A standard set
of questions was asked during this interview to determine if the pati
ent had explicit memory of any event from induction of anesthesia to r
ecovery of consciousness. Results: Nine patients did not complete a po
stoperative interview because of death (n = 7) or postoperative confus
ion (n = 2). The last memory before surgery reported in 420 (69.1%) pa
tients was waiting in the holding area at the operating suite, and in
the remaining 188 (30.9%) patients it was lying on the operating table
before induction of anesthesia. Two patients (0.3%) had explicit memo
ry of intraoperative events. One of the two patients also had explicit
memory of pain. Neither patient reported adverse psychological sequel
ae. Conclusions: The authors report an incidence of awareness in fast-
track cardiac anesthesia of 0.3%. This is the lowest incidence of awar
eness currently reported during cardiac surgery. This low incidence of
awareness may be related to the use of a balanced anesthetic techniqu
e involving the continuous administration of volatile (isoflurane) or
intravenous (propofol) anesthetic agents before, during, and after car
diopulmonary bypass.