Bovier Anton et al., Crossing a fitness valley as a metastable transition in a stochastic population model, Annals of applied probability , 29(6), 2019, pp. 3541-3589
We consider a stochastic model of population dynamics where each individual is characterised by a trait in {0,1,.,L} { 0 , 1 , . , L } and has a natural reproduction rate, a logistic death rate due to age or competition and a probability of mutation towards neighbouring traits at each reproduction event. We choose parameters such that the induced fitness landscape exhibits a valley: mutant individuals with negative fitness have to be created in order for the population to reach a trait with positive fitness. We focus on the limit of large population and rare mutations at several speeds. In particular, when the mutation rate is low enough, metastability occurs: the exit time of the valley is an exponentially distributed random variable.