BIOSYNTHESIS OF CHALEPIN IN RUTA-GRAVEOLENS

Authors
SHARMA RB RAJ K KAPIL RS
Citation
Rb. Sharma et al., BIOSYNTHESIS OF CHALEPIN IN RUTA-GRAVEOLENS, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 37(3), 1998, pp. 247-251
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry → ACNP
ISSN journal
03764699
Volume
37
Issue
3
Year of publication
1998
Pages
247 - 251
Database
ISI
SICI code
0376-4699(1998)37:3<247:BOCIR>2.0.ZU;2-3
Abstract
Biosynthesis of chalepin 15 has been studied. Incorporation of 3-(1,1- dimethylallyl)-7-hydroxycoumarin in 15 indicates that it is the key in termediate for the biosynthesis of chalepin in Ruta graveolens. Utilis ation of gravelliferone 12 into chalepin supported the hypothesis that the origin of dihydrofuran moiety in chalepin, is via prenylation at Ca followed by oxidative cyclisation with neighbouring hydroxyl functi on.