SYNTHESIS, ANTIMALARIAL AND ANTIBACTERIAL ACTIVITY OF 1-CHLORO-2-FORMYLCARBAZOLE AND PYRAZOLO[3,4-A]CARBAZOLE DERIVATIVES

Authors
SEKAR M PRASAD KJR
Citation
M. Sekar et Kjr. Prasad, SYNTHESIS, ANTIMALARIAL AND ANTIBACTERIAL ACTIVITY OF 1-CHLORO-2-FORMYLCARBAZOLE AND PYRAZOLO[3,4-A]CARBAZOLE DERIVATIVES, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 37(3), 1998, pp. 314-317
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry → ACNP
ISSN journal
03764699
Volume
37
Issue
3
Year of publication
1998
Pages
314 - 317
Database
ISI
SICI code
0376-4699(1998)37:3<314:SAAAAO>2.0.ZU;2-3
Abstract
1-Oxo-1,2,3,4-tetrahydrocarbazoles 1a-f on reaction with Vilsmeier Haa ck reagent (DMF/POCl3) furnish the respective 1-chloro-2-formylcarbazo le derivatives 2a-f which on treatment with hydrazine hydrate in ethan ol yield pyrazolo[3,4-a]carbazole derivatives 3a-f. All the chloro for myl compounds 2a-f have been tested for their antimalarial activity ag ainst mosquito species and antimicrobial activities in comparison with chloroamphenicol as a reference compound.