UP-REGULATION OF THIOREDOXIN EXPRESSION IN MOTOR-NEURONS AFTER NERVE INJURY

A substantial up-regulation of thioredoxin, a dithiol/disulfide oxido- reductase, in adult rat motoneurons following hypoglossal nerve axotom y, was demonstrated by using both in situ hybridization and immunohist ochemistry. Although thioredoxin is normally accumulated more in the n ucleus of a motoneuron rather than in the cytoplasm, a dramatic increa se of thioredoxin in the cytoplasmic region after nerve injury was obs erved. The up-regulation of mRNA lasted more than 9 weeks, whereas, th e detectable up-regulation of protein was observed for more than 5 wee ks. (C) 1998 Elsevier Science B.V. All rights reserved.