IN-VIVO RADIOLABEL QUANTIFICATION IN SMALL-ANIMAL MODELS

Current developments in emission tomography especially designed for sm all-animal imaging are presented. Adaptations of the human tomography principles take advantage of the smaller field of view to achieve abou t 2-mm usable resolution. Some evaluations in rat tomography are prese nted, and the problems of limiting resolution of PET and SPECT systems are discussed. Finally, a new approach that more specifically takes i nto account the parameters induced by in vivo quantification in rodent s is presented. NUCL MED BIOL 25;8:731-742, 1999. (C) 1999 Elsevier Sc ience Inc.