TOPIRAMATE EFFICACY IN INFANCY

Topiramate is a sulfamate-substituted monosaccharide that has demonstr ated efficacy as an antiepileptic drug in adults with partial onset se izures. Experience in children has been limited, but early reports hav e supported its safety and effectiveness in children as young as 2 yea rs of age. In two infants ages 12 and 9 months, respectively, with par tial seizures, the authors report excellent efficacy with good tolerab ility at doses up to 7.7 mg/kg, Although long-term safety and possible adverse sequelae have not been fully established in children, topiram ate may represent an option for infants with high seizure frequency un responsive to standard antiepileptic drugs. (C) 1998 by Elsevier Scien ce Inc. All rights reserved.