New G -formula for the sequential causal effect and blip effect of treatment in sequential causal inference

Citation
Xiaoqin Wang et Li Yin, New G -formula for the sequential causal effect and blip effect of treatment in sequential causal inference, Annals of statistics , 48(1), 2020, pp. 138-160
Journal title
ISSN journal
00905364
Volume
48
Issue
1
Year of publication
2020
Pages
138 - 160
Database
ACNP
SICI code
Abstract
In sequential causal inference, two types of causal effects are of practical interest, namely, the causal effect of the treatment regime (called the sequential causal effect) and the blip effect of treatment on the potential outcome after the last treatment. The well-known G-formula expresses these causal effects in terms of the standard parameters. In this article, we obtain a new G-formula that expresses these causal effects in terms of the point observable effects of treatments similar to treatment in the framework of single-point causal inference. Based on the new G-formula, we estimate these causal effects by maximum likelihood via point observable effects with methods extended from single-point causal inference. We are able to increase precision of the estimation without introducing biases by an unsaturated model imposing constraints on the point observable effects. We are also able to reduce the number of point observable effects in the estimation by treatment assignment conditions.