Spatial Moran models I. Stochastic tunneling in the neutral case

Citation
Durrett, Richard et Moseley, Stephen, Spatial Moran models I. Stochastic tunneling in the neutral case, Annals of applied probability , 25(1), 2015, pp. 104-115
ISSN journal
10505164
Volume
25
Issue
1
Year of publication
2015
Pages
104 - 115
Database
ACNP
SICI code
Abstract
We consider a multistage cancer model in which cells are arranged in a d-dimensional integer lattice. Starting with all wild-type cells, we prove results about the distribution of the first time when two neutral mutations have accumulated in some cell in dimensions d.2, extending work done by Komarova [Genetics 166 (2004) 1571.1579] for d=1.