Ba. Sampson et al., METASTASIZING MIXED TUMOR OF THE PAROTID-GLAND - A RARE TUMOR WITH UNUSUALLY RAPID PROGRESSION IN A CARDIAC TRANSPLANT RECIPIENT, Modern pathology, 11(11), 1998, pp. 1142-1145
We report the case of a 69-year-old man who had a mixed tumor (pleomor
phic adenoma) removed from his parotid gland 3 years after orthotopic
heart transplantation. Two years later, he presented with widely metas
tatic mixed tumor, which resulted in his death within 6 months. Metast
atic mixed tumor is histologically identical to a benign mixed tumor,
but it inexplicably metastasizes. Such tumors are rare and have not be
en reported to date in a transplant recipient. This case illustrates t
he rapid and aggressive course that malignancies can follow in an immu
nosuppressed population. Mixed tumors are common salivary neoplasms, s
o transplant recipients should be carefully followed after resection f
or evidence of metastatic spread.