EFFECTS OF SURFACE-ACTIVE AGENT ON THE SIZE, SHAPE AND HARDNESS OF MICROCRYSTALLINE CELLULOSE MAIZE STARCH PELLETS PREPARED BY AN EXTRUSION-SPHERONIZATION TECHNIQUE/
R. Junnila et al., EFFECTS OF SURFACE-ACTIVE AGENT ON THE SIZE, SHAPE AND HARDNESS OF MICROCRYSTALLINE CELLULOSE MAIZE STARCH PELLETS PREPARED BY AN EXTRUSION-SPHERONIZATION TECHNIQUE/, STP PHARMA SCIENCES, 8(4), 1998, pp. 221-226
The effects of non-ionic surface-active agent on the size, shape and h
ardness of microcrystalline cellulose/maize starch pellets prepared by
an extrusion-spheronization technique were studied. Purified water co
ntaining 0 to 3% (w/w) polysorbate 80 was used as a granulation liquid
. All pellet formulations obtained were well-flowing and mechanically
very strong. The addition of a non-ionic surface-active agent decrease
d the amount of fines but increased the over-sized pellets. The inclus
ion of surface-active agent also improved the shape and the surface ch
aracteristics of the pellets. The pellets became rounder, but it was o
bvious that there was only slight improvement after adding more than 1
% surface-active agent in the granulation liquid. The roughness of the
pellet surfaces decreased in relation to the concentration of the sur
face-active agent. The results suggest that the addition of non-ionic
surface-active agent improves the wetting and thereby the rounding of
pellets containing microcrystalline cellulose and native maize starch
as a co-filler, but the effect is not sufficient to produce fully roun
d pellets.