ADVERSE-EFFECTS OF VIGABATRIN IN ANGELMAN-SYNDROME

Authors
KUENZLE C STEINLIN M WOHLRAB G BOLTSHAUSER E SCHMITT B
Citation
C. Kuenzle et al., ADVERSE-EFFECTS OF VIGABATRIN IN ANGELMAN-SYNDROME, Epilepsia, 39(11), 1998, pp. 1213-1215
Citations number
15
Categorie Soggetti
Clinical Neurology
Journal title
Epilepsia → ACNP
ISSN journal
00139580
Volume
39
Issue
11
Year of publication
1998
Pages
1213 - 1215
Database
ISI
SICI code
0013-9580(1998)39:11<1213:AOVIA>2.0.ZU;2-S
Abstract
New antiepileptic drugs designed for enhancing GABAergic inhibition, s uch as vigabatrin (VGB) may be effective in Angelman syndrome (AS), be cause associated convulsions could be related to a reduced GABA-recept or density or receptor abnormality. From our preliminary experiences i n four children with AS treated with VGB, we conclude that it may indu ce and increase seizures in patients with AS.