PSEUDOTUMOR CEREBRI AFTER VARICELLA

Thrombotic complications in children with varicella are well known. Tr ansient protein S deficiency due to the presence of an anti-protein S antibody seems to be responsible at least in part. In an 8-year-old gi rl, pseudotumour cerebri with abducens palsy and ileofemoral vein thro mbosis occurred 3 weeks after chickenpox. A transient elevation of ant i-protein S auto-antibodies was identified. Under treatment with hepar in the pseudotumour cerebri rapidly disappeared but the iliofemoral th rombosis persisted, Conclusion Thrombotic complications after varicell a might be mediated at least in part by antibodies againstr protein S. Early recognition of this condition permits appropriate treatment wit h recombinant tissue-type plasminogen activator.