PPAR-GAMMA-3 MESSENGER-RNA - A DISTINCT PPAR-GAMMA MESSENGER-RNA SUBTYPE TRANSCRIBED FROM AN INDEPENDENT PROMOTER

PPAR gamma is a member of the peroxisome proliferator activated recept ors (PPAR) subfamily of nuclear receptors, So far two PPAR gamma isofo rms, PPAR gamma 1 and PPAR gamma 2, were known in mammals. We describe the structure of a novel human PPAR gamma subtype, PPAR gamma 3, The PPAR gamma 3 mRNA is transcribed from a novel promoter localized 5' of exon A2, PPAR gamma 3 mRNA expression was restricted to adipose tissu e and large intestine. Similar to human PPAR gamma 1 and -2, PPAR gamm a 3 is activated by thiazolidinediones and prostaglandin J derivatives and binds with high affinity to a PPRE. (C) 1998 Federation of Europe an Biochemical Societies.