Local alignment of Markov chains

Citation
Hansen, Niels Richard, Local alignment of Markov chains, Annals of applied probability , 16(3), 2006, pp. 1262-1296
ISSN journal
10505164
Volume
16
Issue
3
Year of publication
2006
Pages
1262 - 1296
Database
ACNP
SICI code
Abstract
We consider local alignments without gaps of two independent Markov chains from a finite alphabet, and we derive sufficient conditions for the number of essentially different local alignments with a score exceeding a high threshold to be asymptotically Poisson distributed. From the Poisson approximation a Gumbel approximation of the maximal local alignment score is obtained. The results extend those obtained by Dembo, Karlin and Zeitouni [Ann. Probab. 22 (1994) 2022.2039] for independent sequences of i.i.d. variables.