Invariance principle for the coverage rate of genomic physical mappings

Authors
Citation
Piau, Didier, Invariance principle for the coverage rate of genomic physical mappings, Annals of applied probability , 15(4), 2005, pp. 2553-2574
ISSN journal
10505164
Volume
15
Issue
4
Year of publication
2005
Pages
2553 - 2574
Database
ACNP
SICI code
Abstract
We study some stochastic models of physical mapping of genomic sequences. Our starting point is a global construction of the process of the clones and of the process of the anchors which are used to map the sequence. This yields explicit formulas for the moments of the proportion occupied by the anchored clones, even in inhomogeneous models. This also allows to compare, in this respect, inhomogeneous models to homogeneous ones. Finally, for homogeneous models, we provide nonasymptotic bounds of the variance and we prove functional invariance results.