A retrospective medical record review was completed for 264 consecutiv
e newborns receiving phototherapy for hyperbilirubinemia to determine
whether a ''rebound'' increase in total serum bilirubin (TSB) level oc
curs after termination of phototherapy. The difference between mean TS
B levels at discontinuation of phototherapy and at rebound was calcula
ted by paired t test. TSB levels at rebound were significantly lower t
han at discontinuation of phototherapy for infants weighing >1800 g (p
ositive and negative Coombs' test results). There were no statisticall
y significant differences among infants in the smaller weight categori
es, regardless of Coombs' test results. Infants completing phototherap
y for hyperbilirubinemia who are otherwise healthy do not require foll
ow-up solely to identify a rebound bilirubin level.