Approximate Ewens formulae for symmetric overdominance selection

Citation
N. Grote, Mark et P. Speed, Terence, Approximate Ewens formulae for symmetric overdominance selection, Annals of applied probability , 12(2), 2002, pp. 637-663
ISSN journal
10505164
Volume
12
Issue
2
Year of publication
2002
Pages
637 - 663
Database
ACNP
SICI code
Abstract
We derive a family of approximate sampling distributions for the symmetric overdominance model of population genetics. The distributions are selective versions of the Ewens Sampling Formula, which gives sample likelihoods under a model of neutral evolution. We draw on basic results for the general selection model of Ethier and Kurtz, and use mathematical tools well-suited for calculating expectations of symmetric functions of Poisson--Dirichlet atoms. We conclude by briefly examining a Human Leukocyte Antigen data set, in light of a distribution conditional on the number of sample atoms.