IN ADDITION TO SEC11, A NEWLY IDENTIFIED GENE, SPC3, IS ESSENTIAL FORSIGNAL PEPTIDASE ACTIVITY IN THE YEAST ENDOPLASMIC-RETICULUM

Authors
FANG H MULLINS C GREEN N
Citation
H. Fang et al., IN ADDITION TO SEC11, A NEWLY IDENTIFIED GENE, SPC3, IS ESSENTIAL FORSIGNAL PEPTIDASE ACTIVITY IN THE YEAST ENDOPLASMIC-RETICULUM, The Journal of biological chemistry, 272(20), 1997, pp. 13152-13158
Citations number
42
Categorie Soggetti
Biology
Journal title
The Journal of biological chemistry → ACNP
ISSN journal
00219258
Volume
272
Issue
20
Year of publication
1997
Pages
13152 - 13158
Database
ISI
SICI code
0021-9258(1997)272:20<13152:IATSAN>2.0.ZU;2-P
Abstract
Among the three characterized subunits comprising the signal peptidase complex of the yeast Saccharomyces cerevisiae (Sec11p, Spc1p, and Spc 2p), only Sec11p is essential for cell growth, signal peptide cleavage , and signal peptidase-dependent protein degradation, Here we report t he cloning of the SPC3 gene encoding the homolog to mammalian signal p eptidase subunit SPC22/23. We find that Spc3p is also required for cel l growth and signal peptidase activity within the yeast endoplasmic re ticulum.