HYALURONIDASE AS ADDITIVE TO INDUCTION CHEMOTHERAPY IN ADVANCED SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK

Authors
KLOCKER J SABITZER H RAUNIK W WIESER S SCHUMER J
Citation
J. Klocker et al., HYALURONIDASE AS ADDITIVE TO INDUCTION CHEMOTHERAPY IN ADVANCED SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK, Cancer letters, 131(1), 1998, pp. 113-115
Citations number
25
Categorie Soggetti
Oncology
Journal title
Cancer letters → ACNP
ISSN journal
03043835
Volume
131
Issue
1
Year of publication
1998
Pages
113 - 115
Database
ISI
SICI code
0304-3835(1998)131:1<113:HAATIC>2.0.ZU;2-A
Abstract
Forty-eight patients with advanced head and neck tumours were treated with irradiation and concomitant chemotherapy with cisplatin, vindesin e and hyaluronidase. The disease-free survival rate at 5 years was 47% . The toxic effects were mucositis (48 patients), nausea (25 patients, vomiting in six patients), bone marrow depression (15 patients) and p eripheral neuropathy (14 patients). The results warrant a randomized t rial. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.