Popliteal masses are frequently referred to vascular surgeons with a p
resumptive diagnosis of popliteal aneurysm. Evaluation by the vascular
surgeon must exclude other diagnoses such as Baker's cyst or neoplasm
. This case report focuses on two patients referred to the vascular su
rgery service with popliteal masses. The first patient had a prior pop
liteal aneurysm repair and the second patient was thought to have a po
pliteal aneurysm without palpable pedal pulses. Evaluation included du
plex ultrasound scanning and imaging with either computed tomography o
r magnetic resonance. After these studies were performed, both patient
s underwent fine needle aspiration (FNA) to determine the cytologic fe
atures of the masses. Final diagnosis for each patient was a soft tiss
ue sarcoma. The differential diagnosis of a popliteal mass should incl
ude both nonneoplastic and neoplastic etiologies. If a neoplasm is sug
gested, FNA can help differentiate between benign versus malignant and
primary versus metastatic disease. Many soft tissue lesions can then
be treated based on clinical, radiologic, and cytologic data without t
he need for open biopsy. Since FNA has a low morbidity rate, the autho
rs recommend early FNA in the evaluation of soft tissue popliteal mass
es. These cases are reported so that vascular surgeons will be prepare
d to evaluate patients with popliteal masses for diagnoses other than
popliteal aneurysms.