ROLE OF CHEWING AND SMOKING-HABITS IN THE ETIOLOGY OF ORAL SUBMUCOUS FIBROSIS (OSF) - A CASE-CONTROL STUDY

Oral submucous fibrosis (OSF), a premalignant and crippling condition of the oral mucous membrane, was studied to identify its relationship to various chewing and smoking habits. Two hundred and thirty-six cons ecutive cases of OSF were compared with 221 control subjects matched f or age, sex and socio-economic conditions. It was found that chewing o f areca nut/quid or pan masala (a commercial preparation of areca nuts , lime, catechu and undisclosed colouring, flavouring and sweetening a gents) was directly related to OSF. Also, pan masala was chewed by a c omparatively younger age group and was associated with OSF changes ear lier than areca nut/quid chewing. However, chewing or smoking tobacco with various other chewing habits did not increase the risk of develop ing OSF. It was also found that frequency of chewing rather than the t otal duration of the habit was directly correlated to OSF.