Focal, demyelinating lesions of the cerebrum mimicking brain tumors ar
e a rare phenomenon, and even rarer in a pediatric population. We docu
ment the case of a 14-year-old female whose clinical, radiological and
operative findings were strongly suggestive of glioma. However, histo
pathology revealed a demyelinating process. This case is significant a
s the lesion could not be distinguished from a glioma at any time in t
he presentation. At 41 months followup, the patient remains stable wit
hout further evidence of demyelination in other areas of the brain. Su
ch a case suggests a cautious note for the pediatrician when presented
with a similar patient and illustrates the importance of consideratio
n of a demyelinating lesion in the differential diagnosis of a mass le
sion in a pediatric population.