SCHIZOPHRENIA AND SEVERE AFFECTIVE-ILLNESS ALTERNATING OVER TIME IN SOME PATIENTS - A HYPOTHESIS

THERE is a small portion of psychiatric patients whose symptom pattern s at one point in their lives suggest a severe affective disorder and at another point a diagnosis of schizophrenia. Shifting symptom patter ns such as this have heretofore been explained as misdiagnosis or dual diagnosis. An alternate hypothesis is offered-that in some patients, mental illness may be expressed in different and discrete ways at diff erent points in their lives, depending upon intrapersonal, interperson al, and biological processes. The rationale for the hypothesis derives from selected follow-up and family studies, treatment and drug effect s, and the observed similarity of abnormal physiological measures in b oth diagnostic groups. Clinical implications are that one cannot alway s rely on family history to support a specific diagnosis on a patient' s first presentation. Furthermore, if a patient subsequently presents with a significant change in symptom pattern, the therapist may wish t o consider a modification of the original treatment regimen. The notio n of shifting symptom patterns does not diminish the usefulness of des criptive diagnostic categories, Rather, it challenges the concept that these categories need be immutable within individuals. Compelling sup port for the hypothesis will necessitate prospective study of patient charts over time.