A. Disch et M. Rohmer, ON THE ABSENCE OF THE GLYCERALDEHYDE-3-PHOSPHATE PYRUVATE PATHWAY FORISOPRENOID BIOSYNTHESIS IN FUNGI AND YEASTS, FEMS microbiology letters, 168(2), 1998, pp. 201-208
The biosynthesis of isopentenyl diphosphate, the central intermediate
of isoprenoid formation, was investigated in the fungus Aschersonia al
eyrodis and the yeast Rhodotorula glutinis. The incorporation of C-13-
labeled glucose or acetate into their isoprenoids showed that ergoster
ol in both micro-organisms, ubiquinone in R. glutinis and dihydro-ubiq
uinone, beta-carotene and triterpenes of the hopane series in A. aleyr
odis were synthesized via the mevalonate pathway. No evidence for the
presence of the alternative mevalonate-independent glyceraldehyde 3-ph
osphate/pyruvate pathway was found. (C) 1998 Federation of European Mi
crobiological Societies. Published by Elsevier Science B.V. All rights
reserved.