PENICILLIN-BINDING PROTEINS OF PATHOGENIC ESCHERICHIA-COLI STRAINS

The penicillin-binding proteins of 11 pathogenic Escherichia coil stra ins, including enteropathogenic, enterotoxigenic, enteroinvasive, ente roaggregative, and enterohemorrhagic E. coli, were detected in gels fo llowing the labeling oi isolated cell envelopes with [H-3]benzylpenici llin. The electrophoretic profiles, sensitivities to and morphological changes induced by beta-lactam antibiotics showed that the penicillin -binding proteins of most pathogenic E. coli possess structural and ph ysiological functions similar to those of E. coil K12. (C) 1998 Publis hed by Elsevier Science B.V. All rights reserved.