AN UPDATE ON METHODS FOR EXAMINING SMALL SPECIMENS FOR FACTORS INDICATIVE OF PROGNOSIS AND RESPONSE TO TREATMENT

Authors
LEDOUSSAL V BRIFFOD M SPYRATOS F BIECHE I
Citation
V. Ledoussal et al., AN UPDATE ON METHODS FOR EXAMINING SMALL SPECIMENS FOR FACTORS INDICATIVE OF PROGNOSIS AND RESPONSE TO TREATMENT, La Semaine des hopitaux de Paris, 74(31-32), 1998, pp. 1175-1177
Citations number
NO
Categorie Soggetti
Medicine, General & Internal
Journal title
La Semaine des hopitaux de Paris → ACNP
ISSN journal
00371777
Volume
74
Issue
31-32
Year of publication
1998
Pages
1175 - 1177
Database
ISI
SICI code
0037-1777(1998)74:31-32<1175:AUOMFE>2.0.ZU;2-8
Abstract
Small specimens are specimens obtained by fine-needle biopsy, core bio psy, or removal of tumors less than 1 cm in diameter. Morphologic and immunohistochemical techniques provide the prognostic information supp lied by hormone receptors, cell growth markers, oncogenes, and tumor s uppressor genes. With fine-needle biopsy specimens; in addition to nuc lear grade, DNA-ploidy, and S phase determinations, the paraffin minib loc method allows to perform the above-mentioned immunohistochemical s tudies. Biochemical methods measure enzymes (protease, thymidine-kinas e, and thymidilate synthetase) of prognostic significance, whereas flo w cytometry evaluates growth; molecular studies are not yet available on a routine basis.