INTERFERENCE OF MYRTOL STANDARDIZED WITH INFLAMMATORY AND ALLERGIC MEDIATORS

Myrtol standardized (Gelomyrtol(R) / Gelomyrtol(R) forte) inhibits the activity of 5-lipoxygenase of human basophil and eosinophil leukocyte s and the formation of leukotriene C-4 as well as 1.8-cineole (eucalyp tol). An increase of prostaglandins (PGE(2)) in mucous membranes of te at cisterns after topical administration of TPA (tetradecanoylphorbol- 13-acetate) was inhibited. In vitro and in vivo studies revealed spasm olytic and broncholytic effects of Myrtol stand. After topical adminis tration into the teat cisterns of the isolated bovine udder Myrtol sta nd. increased the surface temperature, comparable to effects of mentho l.