SYNTHESIS AND BIOLOGICAL-ACTIVITY OF CHELATOR-PEPTIDE T-CONJUGATES

The solid phase procedure was used to prepare two peptide T derivative s in which the 4-[(1,4,8,11- tetraazacyclotetradec-1-yl)methyl]benzoyl unit is linked to their N-terminus. In a human monocyte chemotaxis as say, both chelator-peptide conjugates showed a high binding property t o the CD4 receptor, comparable to the parent H-D-Ala-Ser-Thr-Thr-Thr-A sn-Tyr-Thr-NH2 and its pentapeptide fragment T(4-8)-NH2. These encoura ging results make the above cyclam-oligopeptides candidates for the de velopment of the CD4 receptor imaging agents.