VALUE OF MOLECULAR MARKERS IN THE INITIAL PHASE OF ORAL ANTICOAGULATION THERAPY AFTER HEART-VALVE REPLACEMENT WITH MECHANICAL PROSTHESES

Authors
DAHM M LOTZ J HAFNER G OELERT H PRELLWITZ W
Citation
M. Dahm et al., VALUE OF MOLECULAR MARKERS IN THE INITIAL PHASE OF ORAL ANTICOAGULATION THERAPY AFTER HEART-VALVE REPLACEMENT WITH MECHANICAL PROSTHESES, Zeitschrift fur Kardiologie, 87, 1998, pp. 42-45
Citations number
8
Categorie Soggetti
Cardiac & Cardiovascular System
Journal title
Zeitschrift fur Kardiologie → ACNP
ISSN journal
03005860
Volume
87
Year of publication
1998
Supplement
4
Pages
42 - 45
Database
ISI
SICI code
0300-5860(1998)87:<42:VOMMIT>2.0.ZU;2-I
Abstract
In a prospective study, 39 patients following aortic or mitral valve r eplacement underwent investigation of molecular markers (prothrombin f ragment F1+2, Factor II) in the initial phase of oral anticoagulation therapy (OAT). The results demonstrate that, despite INR being in the depicted range, the levels of the molecular markers remained high, ind icating an increased risk of thromboembolic events. This leads to the conclusion that molecular markers are superior to INR in the monitorin g of the early phase of OAT.