T. Aktug et al., AMNIO-ALLANTOIC FLUID EXCHANGE FOR PREVENTION OF INTESTINAL DAMAGE INGASTROSCHISIS II - EFFECTS OF EXCHANGE PERFORMED BY USING 2 DIFFERENTSOLUTIONS, European journal of pediatric surgery, 8(5), 1998, pp. 308-311
The prevention of intestinal damage in gastroschisis was reported afte
r amnio-allantoic fluid (AAF) exchange using serum saline. However it
is not clear why AAF exchange prevents intestinal damage. Are some har
mful chemicals withdrawn from AAF by exchange or sodium content of AAF
is merely increased? A study was planned to find the end results of A
AF exchange performed by using two different solutions in the chicken
embryo gastroschisis model. After creation of gastroschisis, three gro
ups were studied, In the first group AAF exchange was not performed. I
n the second group AAF exchange was performed using 0.075% NaCl soluti
on (physiologic saline for chicken). In the third group AAF exchange w
as performed using 0.054% NaCl plus 1% dextose solution. Exchange with
two different solutions prevented cellular infiltration and fibrous p
eel formation in intestines which are observed in the non-treatment gr
oup. In the third group, intestinal edema was an additional pathologic
finding. This study shows that in gastroschisis, the intestines outsi
de the abdominal cavity are very sensitive to the quality of the fluid
in which they are bathed. The intestinal damage resembling that encou
ntered in human gastroschisis can be prevented by removing the harmful
chemicals from AAF by exchange.