INCREASED ARTERIAL DISTENSIBILITY IN POSTMENOPAUSAL HYPERTENSIVE WOMEN WITH AND WITHOUT HORMONE REPLACEMENT THERAPY AFTER ACUTE ADMINISTRATION OF THE ACE-INHIBITOR MOEXIPRIL
J. Blacher et al., INCREASED ARTERIAL DISTENSIBILITY IN POSTMENOPAUSAL HYPERTENSIVE WOMEN WITH AND WITHOUT HORMONE REPLACEMENT THERAPY AFTER ACUTE ADMINISTRATION OF THE ACE-INHIBITOR MOEXIPRIL, Cardiovascular drugs and therapy, 12(4), 1998, pp. 409-414
Citations number
27
Categorie Soggetti
Pharmacology & Pharmacy","Cardiac & Cardiovascular System
Menopause and essential hypertension are associated with a decreased c
ompliance and distensibility of the arteries. ACE inhibitors have been
shown to improve arterial distensibility. Hormone replacement therapy
(HRT), especially estrogens, could have a positive influence through
their atheroprotective, vasodilative, and blood pressure-lowering effe
ct. The vascular interactions of HBT and ACE inhibitors, like moexipri
l hydrochloride, have not been investigated so far. This trial was int
ended to assess the effect of combined sequential HRT for 25 days on a
cute changes in arterial distensibility after a single oral dose of 15
mg moexipril hydrochloride in postmenopausal women with borderline to
mild essential hypertension. This study had a monocentric, randomized
, parallel-group design, and was open for moexipril, and double-blind,
and placebo-controlled for HRT. Assessment of arterial distensibility
was by automatic noninvasive measurement of the carotid-femoral pulse
wave velocity (PWV). The PWV and the pulse pressure decreased signifi
cantly after a single oral dose of 15 mg moexipril. An influence of HR
T on the changes in the PWV and pulse pressure could not be seen. The
plasma concentrations of renin increased and of aldosterone decreased
after moexipril administration. Arterial function improves after acute
administration of 15 mg moexipril in postmenopausal women with mild t
o moderate essential hypertension. The changes in PWV and pulse pressu
re are of similar magnitude in women with and without HRT.